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  • Title: Gentamicin nephrotoxicity in cadmium, lead and mercury pretreated rats.
    Author: Viau C, Bernard A, Lauwerys RR, Tulkens P, Laurent G, Maldague P.
    Journal: Toxicology; 1983 May; 27(1):15-25. PubMed ID: 6437016.
    Abstract:
    The effect of a previous chronic exposure to cadmium, lead or inorganic mercury on the nephrotoxic potential of gentamicin was investigated in female Sprague-Dawley rats. A daily dose of 10 mg gentamicin/kg body weight/day was administered for 21 days to rats having a renal load of 168 micrograms Cd, 35 micrograms Pb or 129 micrograms Hg/g whole kidney. Urine analysis suggests an attenuation of the nephrotoxic potential of gentamicin while a microscopical examination of kidneys indicates a superimposition of the effects of the metals and the antibiotics. The only clear interaction observed consists in a reduction of gentamicin accumulation in the cortex of cadmium-treated animals. It is concluded that none of the metal pretreatments potentiates the nephrotoxic effects of gentamicin.
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