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  • Title: Recovery from mitomycin C-induced hemolytic uremic syndrome. A case report.
    Author: Verwey J, Boven E, van der Meulen J, Pinedo HM.
    Journal: Cancer; 1984 Dec 15; 54(12):2878-81. PubMed ID: 6437662.
    Abstract:
    Mitomycin C (MMC) is a cytotoxic agent that may induce a hemolytic uremic syndrome (HUS) with severe renal insufficiency. Of all reported patients with terminal renal failure only two survived with chronic hemodialysis. A patient with advanced gastric cancer in complete remission, who developed MMC-induced HUS, is reported; hemodialysis was necessary because of oliguria. Hemolysis subsided, and after addition of captopril renal function recovered partially. The patient is alive 6 months after discontinuation of hemodialysis. Recently she developed brain metastases. Symptoms of hemolysis did not recur. The pathogenesis and treatment of HUS are discussed.
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