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  • Title: Fanconi anaemia cells are not uniformly deficient in unhooking of DNA interstrand crosslinks, induced by mitomycin C or 8-methoxypsoralen plus UVA.
    Author: Poll EH, Arwert F, Kortbeek HT, Eriksson AW.
    Journal: Hum Genet; 1984; 68(3):228-34. PubMed ID: 6437965.
    Abstract:
    Fanconi anaemia (FA) cells are extremely sensitive to crosslinking agents, e.g. mitomycin C, but only moderately sensitive to trimethylpsoralen plus UVA. Evidence has been reported suggesting that there is a deficient DNA crosslink repair mechanism in FA cells, but others failed to confirm this conclusion using other methods and other crosslinking agents. We reinvestigated the mitomycin C and 8-methoxypsoralen crosslink repair in FA cells with a high sensitivity to mitomycin C. Although an essentially similar methodology was used to that previously described, no difference between the control and FA cell strains was observed, neither for mitomycin C- nor for 8-methoxypsoralen-induced crosslinks.
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