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  • Title: 'Incomplete' pyroglobulin-gamma disease in a patient with osteosclerotic myeloma.
    Author: Ruiz-Arguelles A, Valls-de-Ruiz M, Dominguez-Barranco A, Ruiz-Arguelles G, Ruiz-Reyes G.
    Journal: Scand J Haematol; 1984 Oct; 33(4):351-5. PubMed ID: 6438794.
    Abstract:
    A 50-year-old female, heterozygous for beta-thalassaemia was found to have a lytic lesion surrounded by osteosclerotic tissue in the 1st lumbar vertebra. Aspiration of the lesion showed 100% atypical plasma cells. The bone marrow contained 17% myeloma cells. Despite normal electrophoresis and immunoelectrophoresis of serum and urine, 'rouleaux' formation was pronounced. Treatment of the serum sample with 2-mercaptoethanol and heat (56 degrees C) disclosed an uncommon pyroglobulin. Analysis of the ammonium sulphate precipitate of the serum by sodium-dodecyl-sulphate polyacrylamide gel electrophoresis revealed a 43 kD component with higher anodic mobility than normal gamma chains. Ultrafiltration column chromatography of the serum revealed a narrow spike of approximately 4 S that contained gamma heavy chain antigenic determinants in addition to normal 7 S IgG.
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