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  • Title: [Repeated, 2-10 fold asparaginase treatments in children with lymphoproliferative diseases].
    Author: Legutko L, Zajaczkowski J, Halikowska-Lacka E, Pituch A, Cyklis R.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1976; 103(5):644-50. PubMed ID: 64404.
    Abstract:
    In 42 children being in the advanced stage of an acute lymphoblastic leukaemia as well in 7 children with lymphosarcoma a total of 83 series of treatment with L-asparaginase were carried out. During the first blastic crisis of acute leukaemia 74% of complete or partial remissions could be obtained by two treatments and 52% by the following ones. The best results were obtained by organ manifestations of acute leukaemia (80% of complete or partial remissions). Less satisfactory results were achieved in treating lymphosarcoma. All remissions were only of a short duration.
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