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  • Title: [Chromosome aberrations in F1 (NZBxNZW) mice--an experimental model of systemic lupus erythematosus].
    Author: Skazkina OIa, Lil'p IG, Pleskovskaia GN, Tugolukova SS, Korogodina IuV.
    Journal: Tsitol Genet; 1984; 18(6):458-9. PubMed ID: 6441320.
    Abstract:
    Spontaneous and mitomycin-C-induced chromosomal aberration level was studied in bone marrow cells of mice F1 (NZBXNZW), an experimental model of systemic lupus erythematosus and in C57BL/6J mice. The chromosome instability level is found to correspond to the degree of the autoimmune process: F1 (NZBXNZW) mice with the highest titer of autoantibodies to DNA has higher chromosomal mutability.
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