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  • Title: [Acceleration of the synthesis of cardiac adenine nucleotides from adenosine as affected by propranolol].
    Author: Giacomelli M, Aussedat J, Lavanchy N, Rossi A.
    Journal: C R Acad Sci III; 1984; 299(19):779-84. PubMed ID: 6442183.
    Abstract:
    DL-propranolol, at a dose of 2 mg . l-1, induced in the isolated rat heart an increase in adenine nucleotide synthesis from exogenous 5 microM adenosine (+20%). If supplied during reperfusion following low-flow ischaemia (0.5 ml . min-1, 30 min.), propranolol annulled the decrease in adenosine incorporation (-23%) provoked by ischaemia. When propranolol was given during ischaemia and reperfusion, ATP degradation during the ischaemic period was reduced and adenosine uptake was strongly stimulated on reperfusion (+60%).
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