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  • Title: Sequential determination of circulating immune complexes during progressive and regressive phases of mouse mastocytoma.
    Author: Bertschmann M, Späth PJ, Nydegger UE, Lüscher EF.
    Journal: J Clin Lab Immunol; 1984 Nov; 15(3):149-54. PubMed ID: 6442352.
    Abstract:
    Circulating immune complexes were determined by 125I-C1q-binding and Raji cell-binding sequentially during distinct phases of progression and regression of a weakly immunogenic murine tumour. No increase in levels of circulating immune complexes was found at any time during tumour development, although reference complexes formed between tumour cell membrane antigens and a murine histocompatibility antigen-directed alloantibody were easily detected by both tests. These findings parallel the absence of humoral antibody during tumour development but are in some contradiction to the pronounced B cell proliferation which was observed in this tumour model. The results add evidence for a more critical evaluation of the role which levels of circulating immune complexes might play in tumour diagnosis and prognosis.
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