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  • Title: Immunological and biochemical studies of an unusual alpha heavy chain protein in a 9-year-old boy.
    Author: Joller PW, Joller-Jemelka HI, Shmerling DH, Skvaril F.
    Journal: J Clin Lab Immunol; 1984 Nov; 15(3):167-72. PubMed ID: 6442353.
    Abstract:
    Protein electrophoresis in a 9-yr-old Libyan boy suffering from intestinal alpha chain disease showed a conspicuous peak in the gamma region. Examination in immunoelectrophoresis with monospecific antisera against IgA revealed a quantitatively important monoclonal gradient. The heavy chain protein in serum, urine and duodenal juice was further analysed immunologically in double diffusion, antigen-antibody crossed electrophoresis and biochemically in gel filtration experiments and SDS PAGE. By these techniques alpha 1 chain aggregates of different molecular weight could be found. Immunofluorescence examination of small intestine biopsies showed abundant plasma cells containing alpha heavy chains but no light chains.
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