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  • Title: Choosing the right intravesical chemotherapeutic agent. Results of an in vitro monolayer cell culture assay.
    Author: Whelan P, Flynn C, Ramsden C.
    Journal: Br J Urol; 1984 Dec; 56(6):655-7. PubMed ID: 6442872.
    Abstract:
    The use of a monolayer cell culture technique is described. Twenty-four superficial bladder tumours have been tested against Thiotepa, Adriamycin and Mitomycin C. Cultures were set up in parallel for a clonogenic assay after the method of Salmon. In the monolayer all 24 tumours grew; 21 showed a greater than 50% inhibition to Mitomycin, 13 to Adriamycin and 6 to Thiotepa. In the clonogenic assays, only 12 grew satisfactorily. It is concluded that this monolayer assay gives a reasonable prediction of the sensitivities of the commonly used intravesical agents.
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