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  • Title: 99mTc-hydroxymethane diphosphonate: a new bone imaging agent with a low tin content.
    Author: Domstad PA, Coupal JJ, Kim EE, Blake JS, DeLand FH.
    Journal: Radiology; 1980 Jul; 136(1):209-11. PubMed ID: 6446106.
    Abstract:
    A prospective double-blind comparison of 99mTc-hydroxymethane diphosphonate (HMDP) and 99mTc-methylene diphosphonate (MDP) as bone-seeking agents was performed with 102 patients. Densitometry showed that both cancellous/compact bone and cancellous bone/soft-tissue ratios were greater with HMDP (p less than 0.05); compact bone/soft-tissue and bone lesion/normal bone ratios were the same with both agents. Bone delineation, soft-tissue uptake, and overall image quality were the same with both agents. The HMDP formulation contained 78% fewer stannous ions and had a longer useful life after technetium labeling than MDP.
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