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  • Title: [Effect of disseminated myocardial necrosis on ATPase activity, Ca2+ transport, and lipid peroxidation in cardiac mitochondrial and microsomal membranes].
    Author: Chernysheva GV, Stoĭda LV, Amarantova GG, Kuz'mina IL.
    Journal: Biull Eksp Biol Med; 1980 May; 89(5):563-5. PubMed ID: 6446946.
    Abstract:
    Isoproterenol-induced (5 mg/kg) disseminated necrosis of the rabbit myocardium led to a decrease in the efficiency of calcium pump of sarcoplasmic reticulum fragments. This was shown by the reduced Ca/ATP ratio, as well as by Ca2+ and Ca2+ ATPase accumulation rate. In these conditions, calcium transport to mitochondria increased. Lipid peroxidation plays a definite role in the impairment of membrane permeability since the concentration of malonic dialdehyde rises in microsomal and mitochondrial fractions.U
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