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  • Title: Effects of sulphydryl compounds on the radiation damage in biologically active DNA.
    Author: Lafleur MV, Woldhuis J, Loman H.
    Journal: Int J Radiat Biol Relat Stud Phys Chem Med; 1980 May; 37(5):493-8. PubMed ID: 6447117.
    Abstract:
    The effect of sulphydryl compounds on the induction of alkali-labile sites and on the contribution of such sites to the inactivation of single-stranded phi X174 DNA was studied. Cysteamine is capable of reacting with DNA radicals, thereby modifying the radiation damage in such a way that the induction of immediate and latent breaks is reduced. This depends on the pH of the solution. With cysteine only, a pH dependent protection, against lethal alkali-labile potential breaks could be observed. The damage other than breaks is not influenced by the presence of sulphydryl compounds.
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