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  • Title: Immune responses to weakly immunogenic murine-leukemia-virus-induced tumors. VIII. Characterization of suppressor cells.
    Author: Deutsch O, Devens B, Naor D.
    Journal: Isr J Med Sci; 1980 Jul; 16(7):538-44. PubMed ID: 6447123.
    Abstract:
    YAC is a Moloney-virus-induced tumor of A mice. YAC-injected A and C57BL/6 mice generated suppressor cells. The suppressive function of the cells was tested by determining the ability of splenocytes from YAC-injected mice to inhibit the in vitro cytotoxic responses of primed splenocytes. It was found that suppressor cells passed through a nylon-wool column did not adhere to the plastic surface and resisted treatment with rabbit antimouse brain serum and guinea-pig complement. Therefore, the suppressor cells were defined operationally as "null" complement. Therefore, the suppressor cells did not demonstrate high efficiency; a relatively high concentration of suppressor cells was required to achieve an effective inhibiting action. These findings are discussed in terms of the heterogeneity of suppressor cells.
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