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  • Title: [Cooperation of B- and T-lymphocytes of the human in vitro and in vivo].
    Author: Ambrosius H, Schäffner H.
    Journal: Z Gesamte Inn Med; 1980 Jan 15; 35(2):38-42. PubMed ID: 6447413.
    Abstract:
    It is reported on the experimental proofs for the existence of a cooperation of different populations of lymphocytes in man. Regulatory lymphocytes play a part in the regulation of the synthesis of immunoglobulins by polyclonally stimulated B-lymphocytes, in the generation of killer-T-cells and in the regulation of the DNA-synthesis by mitogenically stimulated T- and B-cells. Typical helper- and suppressor-effects may be proved. Disturbances of lymphocytic interactions may be a cause for the development of immune deficiency diseases. It is very probable that also in several chronic infections a dysfunction of regulatory T-lymphocytes is present.
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