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  • Title: [Investigations concerning the mechanism of contrast damage. The significance lipophilia (author's transl)].
    Author: Gottlob R, Knapp G, Porschinski K, Saghir F.
    Journal: Rofo; 1980 Feb; 132(2):204-7. PubMed ID: 6448209.
    Abstract:
    The damaging action on vascular endothelia of meglumin iothalamate and of meglumin ioxitalamate was tested on the rat aorta. Ioxitalamate was significantly better tolerated than iothalamate. The octanol-water-partition coefficient of various contrast media was evaluated by assessing the iodine content of the octanol phase after mixing. The coefficients found were about 100 fold lower than the coefficients computed by Levitan and Rapoport. The significance of the octanol-water-partition coefficient for endothelial injuries caused by contrast media is disputed.
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