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  • Title: Role of ornithine decarboxylase in cardiac growth and hypertrophy.
    Author: Bartolome J, Huguenard J, Slotkin TA.
    Journal: Science; 1980 Nov 14; 210(4471):793-4. PubMed ID: 6449079.
    Abstract:
    Inhibition of cardiac ornithine decarboxylase (ODC) by alpha-difluoromethylornithine (DFMO) did not prevent normal cardiac growth in mature rats but attenuated isoproterenol-induced hypertrophy. Hypertrophy caused by triiodothyronine was not prevented by DFMO. There appear to be both ODC-dependent and ODC-independent processes contributing to the subcellular mechanisms associated with growth, which must be considered in the potential laboratory and clinical use of DFMO.
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