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  • Title: Suppressor activity of blood lymphocytes from guinea-pigs treated with ALS.
    Author: Rudnicka W.
    Journal: Immunology; 1980 Mar; 39(3):435-40. PubMed ID: 6449472.
    Abstract:
    PHA-induced transformation of guinea-pig lymphocytes was profoundly inhibited by the injection of antilymphocyte serum (ALS). This effect, seen 24 h after ALS administration, disappeared within 3 days. Lymphocytes of animals injected with ALS 24 h earlier inhibited the blast transformation of autologous normal lymphocytes. The supernatants of short term cultures of such cells, even after pre-treatment with puromycin, exhibited the same inhibitory activity. It is suggested that the immunosuppressive effect of ALS is not limited to its direct action on lymphocytes.
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