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  • Title: Normal T cell regulation of IgG synthesis in systemic lupus erythematosus.
    Author: Nies KM, Stevens RH, Louie JS.
    Journal: J Clin Lab Immunol; 1980 Sep; 4(2):69-75. PubMed ID: 6449594.
    Abstract:
    The regulation of pokeweed mitogen (PWM) stimulated IgG synthesis by peripheral blood mononuclear cells (PBL) was studied in patients with systemic lupus erythematosus (SLE) and controls. The helper-T, suppressor-T and B cell functions of SLE-PBL were separately evaluated and compared to the functions of control lymphocyte populations. SLE-T cells function normally both in helper and suppressor modulation of PWM-stimulated IgG secretion by control or autologous B cells. The SLE-B cell, however, fails to synthesize normal quantities of IgG when cultured under conditions that induce maximal stimulation. While other studies document abnormal Con A induced suppressor cell function in SLE, this study shows that normal functioning populations of SLE-suppressor T cells exist in the peripheral blood.
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