These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Phototoxicity of the chemotherapeutic agents hematoporphyrin D, meso-tetra(p-sulfophenyl)porphine and zinc-tetra(p-sulfophenyl)porphine.
    Author: Grenan M, Tsutsui M, Wysor M.
    Journal: Res Commun Chem Pathol Pharmacol; 1980 Nov; 30(2):317-27. PubMed ID: 6449725.
    Abstract:
    Interest in natural and synthetic porphyrins as tumor-localizing agents, tumor-photoinactivating agents and anti-trypanosomal drugs prompted a laboratory evaluation of the phototoxic potency of these compounds. At UV wavelengths greater than 3200A three porphyrin compounds were significantly more phototoxic than the positive control, 6,8-dichloro-2-phenyl-alpha-2-piperidyl-4-quinoline methanol. Phototoxicity was seen after intraperitoneal administration but not after oral administration. Minimum effective phototoxic doses of Hematoporphyrin D were < 2.40 mg; TPPS < 1.25 mg/kg, and ZnTPPS < 1.24 mg/kg. Hematoporphyrin D produced toxic deaths at doses of 37.5-150 mg/kg.
    [Abstract] [Full Text] [Related] [New Search]