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  • Title: Mechanisms of organic cation transport in kidney plasma membrane vesicles: 2. delta pH studies.
    Author: Holohan PD, Ross CR.
    Journal: J Pharmacol Exp Ther; 1981 Feb; 216(2):294-8. PubMed ID: 6450830.
    Abstract:
    The active step in the renal secretion of the organic cation N1-methylnicotinamide has been proposed to be the translocation across the luminal membrane. The presence of a H+:N1-methylnicotinamide antiport system has been found in luminal membrane vesicles isolated from dog kidney cortex but not in the antiluminal membrane. The conclusion reached is that N1-methylnicotinamide secretion is "secondarily active" and is driven by a proton gradient (urine to cell). The ph gradient in turn is created by the Na+:H+ antiport which is present in the luminal membrane. Therefore, two functionally linked antiport systems supply the energy for the active secretion of cationic drugs.
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