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  • Title: [Oral treatment of severe forms of acne with 13-cis-retinoic acid. Clinical results (author's transl)].
    Author: Plewig G, Wagner A, Braun-Falco O.
    Journal: MMW Munch Med Wochenschr; 1980 Sep 19; 122(38):1287-93. PubMed ID: 6450893.
    Abstract:
    A new, very effective method of treating severe forms of acne (papuplopustular, conglobate, fulminating and tetrad) is the oral administration of 13-cis-retinoic acid. The results described by Peck et al. (1979) in 14 patients are demonstrated in detail in 18 patients. In the initial therapy 1 to 2 mg/kg body weight were administered daily for 12 weeks without any other local or systemic treatment. In the second phase of the study half the patients continued treatment with 0.5 mg/kg body weight 13-cis-retinoic acid, the other half remaining without any further therapy. All inflammatory lesions healed after 12-16 weeks, sebum production was largely reduced. 13-cis-retinoic acid represents a remarkable turn in the treatment of most severe acne.
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