These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of impromidine (SK&F 92676) on the isolated papillary muscle of the guinea-pig.
    Author: Bertaccini G, Coruzzi G.
    Journal: Br J Pharmacol; 1981 Feb; 72(2):197-9. PubMed ID: 6452187.
    Abstract:
    Impromidine was found to have a positive inotropic effect on the isolated papillary muscle from the guinea-pig. The dose-response curve to impromidine was shifted to the right by cimetidine and ranitidine. Impromidine was 35 times more potent than histamine but with a maximal response of only 81% that obtained with histamine. This difference, which was statistically significant (P < 0.005), suggested that impromidine acts as a partial agonist at the histamine H2-receptors of the papillary muscle as has been observed in other tissues.
    [Abstract] [Full Text] [Related] [New Search]