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  • Title: [Clinical results of cefoperazone in pediatric infections (author's transl)].
    Author: Miyao M, Kuroda Y, Tanaka H, Mizui M, Uyama Y, Yuasa Y.
    Journal: Jpn J Antibiot; 1980 Sep; 33(9):931-4. PubMed ID: 6452542.
    Abstract:
    In order to evaluate effectiveness of cefoperazone (CPZ) in the treatment of bacterial infections of children, the clinical studies were carried out. CPZ was administered by one-shot injection to 28 patients at daily dose of 50 approximately 160 (average 89.7) mg/kg in 3 approximately 4 divided dose for 2 approximately 10 (average 5.6) days. The overall efficacy rate in 28 cases was 92.9%, i.e., excellent in 16 (57.1%), good in 10 (35.7%), fair in 1 (3.6%) and poor in 1 case (3.6%). Temporary rise of GOT and GPT or only GOT was observed in each 1 case out of 28 cases (7.1%), but any other abnormality was not observed throughout this series. Based on the above results, CPZ was thus considered to be a useful antibiotic in treatment of pediatric infections caused by Gram-positive cocci and Gram-negative rods.
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