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Title: [Cefoperazone--a new cephalosporin antibiotic with broader spectrum of activity]. Author: Jendroschek T, Belmega G, Lode H, Kemmerich B, Dzwillo G, Koeppe P, Wagner J. Journal: Med Klin; 1981 Feb 13; 76(4):102-6, 70. PubMed ID: 6452567. Abstract: Concentration of Cefoperazone in serum and urine was determined after 1g (bolus injection) and 2g drip-infusion over a 30-minute-period in 10 healthy volunteers. The pharmacokinetic analysis was performed using an open 3-compartment model. Renal clearance was determined in three volunteers and indicates an expansive extrarenal elimination rate. 31 patients mainly with severe bronchopulmonary infections were treated with 2.0--6.0 g/day of Cefoperazone. The therapeutic results were favourable, the toleration of the drug was good.[Abstract] [Full Text] [Related] [New Search]