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  • Title: The effect of Ca+ free medium on the two different tricarboxylate cycles in the rat brain cortex slices.
    Author: Turský T, Lassánová M.
    Journal: Physiol Bohemoslov; 1981; 30(1):11-7. PubMed ID: 6452633.
    Abstract:
    The authors studied the effect of calcium-free saline-glucose medium on labelled amino acid and [14C]CO2 synthesis from U-[14C]-glucose and 1-[14C]-acetate in rat brain cortex slices. Respiration was stimulated parallel with increased synthesis of labelled amino acids and of [14C]CO2 from glucose to [to 150 % and 170 % respectively]. Specific glutamate, aspartate and neutral amino acid activity rose, GABA and glutamine were unaffected. Amino acid synthesis from 1-[14C]-acetate was inhibited [58%], while [14C]CO2 release was unchanged. This indicates that oxygen consumption via the tricarboxylase cycle associated with the small glutamate pool [and probably localized in the glia cells] did not alter in calcium-free medium, although conversion to amino acids was impaired.
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