These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Fosfomycin, a new antibiotic: in vitro activity compared with mezlocillin, cefuroxime and gentamicin].
    Author: Lindenschmidt EG, Schassan HH.
    Journal: Immun Infekt; 1980; 8(4):121-6. PubMed ID: 6453080.
    Abstract:
    In vitro investigations with fosfomycin, mezlocillin, cefuroxime, and gentamicin against staphylococci, enterobacteriaceae an pseudomonadaceae were carried out by Agar Dilution method on Mueller-Hinton agar. The fosfomycin breakpoint for the low dosage of 2-3 times 3 g per infusion daily was defined with 16 micro g/ml and for the high dosage of 2-3 times 5 g fosfomycin per infusion with 64 micro g/ml. At a concentration of 16 micro g/l fosfomycin more than 90% of the cultures of staph. aureus (penicillin-resistant), e. coli, proteus mirabilis an proteus vulgaris examined were inhibited. At a concentration of less than 64 micro g/ml fosfomycin 80 toi 100% of the cultures of serratia marcescens, klebsiella pneumoniae, enterobacter cloacae, proteus morgani et rettgeri and pseudomonas aeruginosa (gentamicin sensitive and resistant) were inhibited. Fosfomycin showed an absolute stability against many Beta-Lactamases of different bacterial species.
    [Abstract] [Full Text] [Related] [New Search]