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  • Title: [Toxicity of pyrazinamide in antituberculous treatments (author's transl)].
    Author: Pretet S, Perdrizet S.
    Journal: Rev Fr Mal Respir; 1980; 8(4):307-30. PubMed ID: 6454227.
    Abstract:
    Pyrazinamide, an antituberculous drug discovered in 1952, was first considered as a toxic drug. As it appeared as a bactericidal drug for the organisms inside macrophages, its usefulness has been re-appraised. In combination with other bactericidal drugs, it contributes to speed up the sterilization of tuberculous lesions. A review of the more recent clinical trials allows to assess the real toxicity of Pyrazinamide. Prescribed at a daily dosage of 30 to 35 mg/kg (1,5 to 2 g daily), it gives no major side effects.
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