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  • Title: Polyclonal human T lymphocyte activation results in the secondary functional activation of the human B lymphocyte.
    Author: Bird AG, Hammarström L, Smith CI, Britton S.
    Journal: Clin Exp Immunol; 1981 Jan; 43(1):165-73. PubMed ID: 6454516.
    Abstract:
    The polyclonal T lymphocyte activators Con A and PHA were demonstrated to induce secretion of IgM and IgG as well as IgA antibodies in cultures of human peripheral blood lymphocytes. A similar response was seen in one-way mixed lymphocyte cultures and the kinetics, dose-response characteristics and optimal culture conditions are presented. The presence of functional T lymphocytes is a prerequisite for in vitro B lymphocyte activation in response to T lymphocyte mitogens. A narrow dose-response profile is a characteristic for both Con A and PHA and polyclonal B cell activation occurred at what have been previously regarded as suboptimal concentrations of these agents. The use of higher doses of these activators failed to generate immunoglobulin-secreting cells despite the presence of early and optimal levels of DNA synthesis in the cultures.
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