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  • Title: Ro 11-1430, a new retinoic acid derivative for the topical treatment of acne.
    Author: Nordin K, Fredriksson T, Rylander C.
    Journal: Dermatologica; 1981; 162(2):104-11. PubMed ID: 6454596.
    Abstract:
    The clinical efficacy and tolerance of a new retinoic acid derivative, Ro 11-1430, in the treatment of acne vulgaris have been compared with those of tretinoin in a double-blind trial with 60 patients during 8 weeks. The efficacy of both drugs was good. Tretinoin showed a tendency to give better effect but this was not statistically significant. However, tolerance of the new derivative was better. 48 of the patients were treated with Ro 11-1430 for another 3 months with good effect and tolerance. In a long-term study, 32 patients with previous irritation of tretinoin have been treated with Ro 11-1430 between 1.5 and 17 months with good tolerance.
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