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  • Title: Effects of inhibitors on mitochondrial adenosine triphosphatase of Crithidia fasciculata: an unusual pattern of specificities.
    Author: Yarlett N, Lloyd D.
    Journal: Mol Biochem Parasitol; 1981 May; 3(1):13-7. PubMed ID: 6454844.
    Abstract:
    The mitochondrial adenosine triphosphatase of the kinetoplastid protozoon, Crithidia fasciculata, is inhibited by oligomycin, venturicidin, triethyltin sulphate, N,N'-dicyclohexylcarbodiimide, leucinostatin, Dio-9 and quercetin, but not spegazzinine or by compounds which interact with the beta-subunit of mitochondrial F1-ATPase (efrapeptin, aurovertin, citreoviridin or 4-chloro-7-nitrobenzofurazan). These results suggest that the F1 portion of the crithidial enzyme has an unusual type of beta-subunit. Further evidence for the atypical nature of this enzyme is provided by the observation that F1-inhibitor proteins from Acanthamoeba castellanii or bovine heart mitochondria do not inhibit the C. fasciculata enzyme activity.
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