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  • Title: [Comparative indices of the formation and protective activity of antibodies during Honk Kong influenza A epidemics].
    Author: Taros LIu, Rumel' NB, Smorodintsev AA.
    Journal: Vopr Virusol; 1981; (1):59-64. PubMed ID: 6455011.
    Abstract:
    In the period of circulation of influenza A/Hong Kong (H3N2) virus and its antigenic varieties in 1969-1976, more than 45,000 serum specimens from patients, donors, and subjects of various ages from permanently observed contingents were examined serologically by HI and CFT. The long persistence in the human population of heterologous immunity to viruses of new or old subtypes was shown to be due to its constant stimulation in the period of any subsequent influenza A epidemic. Under conditions of a natural epidemic process as well as in the studies of the epidemiological effectiveness of live influenza vaccines the protective role of not only homologous but also heterologous (although to a lower extent) antibody was confirmed. The protective role of heterologous antibody decreased gradually with progressive variability of influenza A virus.
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