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  • Title: The effect of disodium-chromoglykate on human serum neutrophil-chemotactic activity in antigen induced bronchospasm.
    Author: Nagy L.
    Journal: Allerg Immunol (Leipz); 1981; 27(1):48-52. PubMed ID: 6455057.
    Abstract:
    The prior administration of disodium-chromoglykate significantly inhibited the increase of serum neutrophil-chemotactic activity in house-dust induced bronchospasm. The serum neutrophil-chemotactic activity was probably mast-cell derived, because of the protective effect of disodium-chromoglykate and it may be related to Neutrophil-chemotactic Factor isolated in human pulmonary tissue. The moderately increased chemotactic activity after prior administration of disodium-chromoglykate in house-dust induced bronchospasm may derive from circulating basophils. The cellular chemotaxis (eosinophil, neutrophil) may has main importance in the pathophysiology of asthma bronchiale. The stimulation of eosinophil-associated effects may provide a new therapeutic line.
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