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  • Title: [Sub-populations of T helper suppressor lymphocytes in diverse dermatoses using monoclonal antibodies. Preliminary results (author's transl)].
    Author: Fulton R, Thivolet J, Garcier F, Gaucherand M.
    Journal: Ann Dermatol Venereol; 1981; 108(3):243-6, 249-50. PubMed ID: 6455084.
    Abstract:
    The total T lymphocyte and T cell subsets were counted in various dermatoses by indirect immunofluorescence using the monoclonal antibodies OKT3, OKT4, OKT8 which distinguish all peripheral T cells, helper T cells and suppressor T cells respectively. In particular, 7 cases of the Sézary syndrome and 7 cases of mycosis fungoides were studied. In addition, 42 other patients with diverse dermatoses such as psoriasis, atopic eczema, bullous disorders, sarcoidosis, lupus erythematosus and leprosy were studied and compared to 20 healthy controls. There was no significant increase in the total T cell percentage in the ratio of helper to suppressor lymphocytes in the Sézary syndrome with a normal balance in mycosis fungoides. Among the other dermatoses only atopic eczema showed a significant increase in the helper/suppressor ratio suggesting an imbalance of T cell subpopulations in this condition.
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