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  • Title: Bronchodilator effects of clemastine, ipratropium, bromide, and salbutamol in preschool children with asthma.
    Author: Groggins RC, Milner AD, Stokes GM.
    Journal: Arch Dis Child; 1981 May; 56(5):342-4. PubMed ID: 6455096.
    Abstract:
    The bronchodilator activity in nebulised salbutamol, ipratropium bromide, clemastine, and a placebo was studied in 14 asthmatic children aged between 3 and 5 years. Changes in lung function were monitored by measuring peak expiratory flow rate and total respiratory resistance using a modification of the forced oscillation technique. Ipratropium bromide produced a degree of bronchodilation similar to that of salbutamol, but the bronchodilatory activity of clemastine was not appreciably better than for the placebo.
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