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  • Title: Effect of histamine H1- and H2-receptor agonists on gamma-aminobutyric acid (GABA) content in hypothalamus and striatum of the rat brain.
    Author: Nowak JZ, Bielkiewicz B.
    Journal: Arch Immunol Ther Exp (Warsz); 1980; 28(6):917-20. PubMed ID: 6455100.
    Abstract:
    The intraventricular administration of histamine in a dose of 500 microgram, and two histamine H2-receptor agonists i.e. 50-250 microgram of dimaprit and 100 microgram of 4-methylhistamine decreased GABA level after 30 min (by approximately 20%) in the hypothalamus, but not in the striatum of the rat brain. The level of GABA was significantly reduced by 100 microgram of dimaprit after 2 h. Drugs selectively stimulating histamine H1-receptor (100 microgram) did not significantly change GABA concentration of the rat hypothalamus. The results suggest the existence of an H2-receptor--mediated histamine--GABA interaction in the rat hypothalamus.
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