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  • Title: Elastogenesis and microfibrillar glycoprotein synthesis by bovine ligamentum nuchae cells in culture.
    Author: Sear CH, Jones CJ, Knight KR, Grant ME.
    Journal: Connect Tissue Res; 1981; 8(3-4):167-70. PubMed ID: 6455240.
    Abstract:
    Cell cultures propagated from fetal bovine ligamentum nuchae were found to accumulate an extensive extracellular matrix containing collagen and elastic fibers when maintained for periods up to 8 weeks. The synthesis by these cells of two glycoproteins, designated MFP I and MFP II, which are immunologically related to components of the elastic fiber microfibrils was investigated. MFP II, apparent mol. t. 300,000, was shown to be a non-collagenous glycoprotein whereas MFP I, apparent mol. wt. 150,000, was found to be a novel collagenous glycoprotein containing hydroxyproline and glycosylated hydroxylysine residues but exhibiting properties of distinct from the known collagens. Two glycoproteins having characteristics similar to MFP I and MFP II were also identified in an extract of the cell layer and in a "microfibrillar protein preparation" from intact nuchal ligament.
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