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  • Title: Failure to interrupt established pregnancy in humans by D-tryptophan-6-luteinizing hormone-releasing hormone.
    Author: Tolis G, Comaru-Schally AM, Mehta AE, Schally AV.
    Journal: Fertil Steril; 1981 Aug; 36(2):241-2. PubMed ID: 6455307.
    Abstract:
    Four women 5 to 8 weeks into pregnancy, scheduled for therapeutic abortions, were given an analog of gonadotropin-releasing hormone, D-tryptophan-6-LHRH, in an effort to interrupt pregnancy. The treatment consisted of 100-micrograms injections, given twice daily for 5 to 10 days. No decline in serum beta-hCG or progesterone was noted, and menstrual extraction was needed in all women for pregnancy interruption. These data indicate that D-Trp-6-LHRH is not effective as an abortifacient in established pregnancy. Treatment with superactive luteinizing hormone-releasing hormone (LHRH) analogs (LHRH-A) for pregnancy termination was studied to determine its efficacy. 4 women, scheduled for abortion, whose last menstrual periods occurred 46-69 days before day of pregnancy diagnosis participated in the study. They were treated twice daily with 100 mcg of LHRH-A, by injection. Treatment lasted from 5-10 days. Blood samples were obtained before and during treatment and were assayed for levels of progesterone, prolactin, and beta-human chorionic gonadotropin subunit. Patient 1 was treated for 10 days, Patient 2 for 5 days, Patient 3 for 6 days, and Patient 4 for 9 days. None of the patients aborted. There were no clinical signs of pregnancy regression; nonoe of the women cramped, nor did they experience any side effects. In addition, there were no declines in the hormones measured; rather levels of progesterone and chorionic gonadotropin rose, as they would with increasing gestation. (e.g., Patient 1 was 50 days from last menstrual period. Her progesterone level before treatment was 19 ng/ml; her chorionic gonadotropin beta-subunit level before treatment was 398 mIU/ml. After treatment, the progesterone level rose to 41 and the gonadotropin level to 472. All women underwent menstrual extraction within 3 days of treatment termination. THere was no evidence that D-Trp-5-LHRH, at the dosage given, could interrupt pregnancy (as it had in rats). Larger doses would also probably be ineffective since the dose used was larger than that known to induce luteolysis.
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