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  • Title: Effect of oral alanine loads on plasma amino acids in oral contraceptive users and control women.
    Author: Potera C, Rose DP.
    Journal: Am J Clin Nutr; 1978 May; 31(5):794-8. PubMed ID: 645627.
    Abstract:
    Plasma amino acids were determined before and after orally administered alanine loads in five women using an estrogen-containing oral contraceptive and four healthy female controls. Oral contraceptive users and significant reductions in fasting plasma valine, methionine, isoleucine, tyrosine, phenylalanine, histidine, glutamic acid, and alpha-aminobutyric acid. With the exception of alpha-aminobutyric acid, these differences between the two groups were eliminated within 3 hr of alanine ingestion. This effect was due to a gradual increase in the plasma amino acids of the oral contraceptive-treated women, plus no change or slight reductions in the controls. Plasma amino acids were determined before and after (30-minute intervals for 3 hours) orally administered alanine loads (200 mg/kg of body weight) in 5 women using estrogen-containing (Ovral or Ortho-Novum 1/50) oral contraceptives (OCs) and in 4 controls. OC users had significantly lower (by paired t-test) fasting concentrations of essential (valine, methionine, isoleucine, tyrosine, and phenylalanine) and nonessential amino acids (histidine, glutamic acid, and alpha-aminobutyric acid) than did controls. After alanine ingestion, these differences disappeared at rates which varied with the individual amino acid. These effects arose because though amino acid levels in controls either remained constant or showed slight decreases, those of OC users gradually increased with time. Although this general trend was evident for both controls and OC groups, changes were not statistically significant when each time point was compared with the zero time value. Histidine and glutamic acid levels reached similar values for the 2 groups as early as 30 minutes after alanine loading; for most amino acids this was achieved by 120 minutes. Exceptions were tyrosine and alpha-aminobutyric acid; the concentrations were still significantly lower in the OC group at 150 and 180 minutes, respectively.
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