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  • Title: Interference with epididymal physiology as possible site of male contraception.
    Author: Reyes A, Chavarría ME.
    Journal: Arch Androl; 1981 Sep; 7(2):159-68. PubMed ID: 6456706.
    Abstract:
    The epididymis as a site for fertility control intervention in males is under experimental research. This is an ideal contraceptive site because epididymal spermatozoa maturation involves several biophysicochemical parameters which can be selectively interrupted. Other advantages to this approach are that there is no chance of mutagenic side effects and the effect on stored spermatozoa produces infertility within days as compared with effects in the testis which require several weeks. A review of the study literature shows that the following morphological, biochemical, and physiological changes in sperm maturation in the epididymis can be the target of contraceptive interference: 1) spermatozoan structural stabilization by the progressive oxidation of SH groups at different cellular structure levels; 2) changes in the spermatozoa energy metabolism; 3) changes in the spermatozoa motility pattern; and 4) the relationship between the sialoglycoproteins in the epididymal milieu and in the sperm cell. The physiological processes occurring in the epididymis are explained. Each of these intervention strategies is explained. Some of these interventions might have an effect also on subsequent sperm capacitation postejaculation.
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