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  • Title: A comparison of skeletal uptakes of three diphosphonates by whole-body retention: concise communication.
    Author: Fogelman I, Pearson DW, Bessent RG, Tofe AJ, Francis MD.
    Journal: J Nucl Med; 1981 Oct; 22(10):880-3. PubMed ID: 6457135.
    Abstract:
    Twenty normal volunteers had measurements of 24-hr whole-body retention (WBR) of three structurally related Tc-99m-labeled phosphonate skeletal imaging agents: (1-hydroxyethylidene) diphosphonate (HEDP), methylene diphosphonate (MDP), and hydroxymethylene diphosphonate (HMDP). The average WBR values, reflecting skeletal uptake, were 18.4, 30.3, and 36.6%, respectively. These results clearly illustrate that slight alterations in diphosphonate molecular structure have a significant effect upon specificity for osseous tissue, and thus may affect skeletal image quality and the usefulness of the WBR technique in diagnosing metabolic bone disease.
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