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  • Title: The effect of polymorphonuclear leukocyte (PMNL) factors on T suppressor cell function in in vitro studies in healthy persons and some autoimmune disorders.
    Author: Czernicki J, Tchórzewski H, Lewicki R, Orzel H.
    Journal: Arch Immunol Ther Exp (Warsz); 1981; 29(3):355-60. PubMed ID: 6457583.
    Abstract:
    Lysosome proteins derived from peripheral blood granulocytes of patients with multiple sclerosis (MS), lupus erythematosus (LE), rheumatoid arthritis (RA) and recurrent uveitis cause the impairment of Con A-induced suppressor cell activity in two-step culture in vitro. This effect is independent of lysosome protease activity. Such a phenomenon, observed in vitro, may cause disturbances in suppressor cell function in the course of the above diseases.
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