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  • Title: Vanadate inhibition of active Ca2+ transport across human red cell membranes.
    Author: Rossi JP, Garrahan PJ, Rega AF.
    Journal: Biochim Biophys Acta; 1981 Nov 06; 648(2):145-50. PubMed ID: 6458333.
    Abstract:
    (1) Vanadate (pentavalent vanadium) inhibits with high affinity (K0.5 = 3 microM) the ATP-dependent Ca2+ efflux in reconstituted ghosts from human red cell. (2) To inhibit Ca2+ efflux vanadate has to have access to the inner surface of the cell membrane (3) The inhibitory effect of vanadate is potentiated by intracellular Mg2+ and by intracellular K+. (4) Ca2+ in the external medium antagonizes the inhibitory effect of vanadate.
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