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  • Title: Tumor promoting and skin irritant diterpene esters of Euphorbia virgata latex.
    Author: Upadhyay R, Samiyeh R, Tafazuli A.
    Journal: Neoplasma; 1981; 28(5):555-8. PubMed ID: 6458773.
    Abstract:
    The mouse ear irritant latex of E. virgata, has been found to contain various skin irritant and non-irritant esters of the diterpene ingenol. In cocarcinogenic assay on dorsal back skin of NMRI mice, acetone extract of this latex produces squamous cell papilloma. Using a combination of biologic and chemical separation techniques one of the initiator-promotor for skin carcinogenesis has been identified as 3-0-2 methyl-decanoyl ingenol.
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