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  • Title: [Concentration of cefoperazone in various tissues of the urogenital system (author's transl)].
    Author: Schalkhäuser K, Adam D.
    Journal: Arzneimittelforschung; 1981; 31(10):1770-2. PubMed ID: 6459099.
    Abstract:
    Within the framework of perioperative short-term prophylaxis against infections, serum and tissue concentrations were investigated after a single i.v. bolus injection of 2.0 g cefoperazone (Cefobis), a semisynthetic cephalosporin parenterally applicable, in 30 patients with a prostatic adenoma. The mean serum concentrations ranged from 82.0 micrograms/ml at 30 min to 41.9 micrograms/ml at 150 min following the injection decreasing continuously. The corresponding mean concentrations in the tissue of prostatic adenoma were 17.8 micrograms/g and 13.9 micrograms/g, the maximum concentrations were found 90 min after the injection with 21.6 micrograms/g. Most differing concentrations were found in 14 kidneys 90 min after injection. The individual values varied between 5.5 micrograms/g and 70.2 micrograms/g. These ranges of variation must be attributed to the differing clinical and histological diagnoses of the collected organs with highly differing degrees of function. Effective levels of 7.0 micrograms/g to 28.9 micrograms/g were found at different times in 13 testes of 14 patients undergoing plastic orchidectomy because of a carcinoma of the prostata. Average concentrations of 10.3 micrograms/g to 13.2 micrograms/g in the ureter, adipose tissue and muscle were within the therapeutically effective range. The high cefoperazone concentrations found in serum and different tissues lead us to expect successful therapy when cefoperazone is used to treat bacterial infections with sensitive pathogens in the urogenital tract.
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