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  • Title: Effect of diphosphonates on the synthesis of prostaglandins in cultured calvaria cells.
    Author: Felix R, Bettex JD, Fleisch H.
    Journal: Calcif Tissue Int; 1981; 33(5):549-52. PubMed ID: 6459147.
    Abstract:
    The calvaria cells cultured for 6 days in the presence of dichloromethanediphosphonate (Cl2MDP) (0.025-250 microM), the synthesis of prostaglandin E2 (PGE2) was inhibited by up to 90%. Inhibition of PGE2 synthesis might be one mechanism whereby this diphosphonate inhibits bone resorption. This effect is not common to all diphosphates since 25 microM 3-amino-1-hydroxypropane-1,1-diphosphonate (AHPDP) stimulated the synthesis of PGE2.
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