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  • Title: Combination bronchodilator therapy in asthma.
    Author: Ruffin RE, McIntyre E, Crockett AJ, Zielonka K, Alpers JH.
    Journal: J Allergy Clin Immunol; 1982 Jan; 69(1 Pt 1):60-5. PubMed ID: 6459357.
    Abstract:
    This study has compared the short-term bronchodilator effects of inhaled anticholinergic (ipratropium bromide) and sympathomimetic (fenoterol) agents alone and in combination in 18 asthmatic patients. the study was of double-blind, placebo-controlled, crossover design. The combination of 60 micrograms ipratropium bromide and 200 micrograms of fenoterol had a greater bronchodilator effect than lower dose combinations or either drug alone. Small but significant gains may be made with combination inhaled bronchodilator therapy.
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