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  • Title: Some characteristics of apurinic sites in single- and double-stranded biologically active phi X174 DNA.
    Author: Lafleur MV, Woldhuis J, Loman H.
    Journal: Nucleic Acids Res; 1981 Dec 11; 9(23):6591-9. PubMed ID: 6459567.
    Abstract:
    With biologically active DNA of the bacteriophage phi X174, both single and double-stranded, some physico-chemical and biological parameters of the depurination reaction are studied. It is shown that in single-stranded DNA each apurinic site is lethal, while in double-stranded RFI-DNA only about 5% of these sites are lethal. Furthermore it is concluded that the apurinic sites are formed at different rates in single- and double-stranded DNA and also the conversion into breaks of the apurinic sites is different for both forms of DNA.
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