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  • Title: [Histidine-rich protein synthesis in the mouse epidermis in the early periods after stimulation of epidermocyte proliferation and the effect of chalones].
    Author: Ketlinskiĭ SA, Parfenova EV.
    Journal: Tsitologiia; 1981 Dec; 23(12):1395-402. PubMed ID: 6460364.
    Abstract:
    Using autoradiographic and biochemical methods, the induction of epidermocyte proliferation in adult rats by plucking was shown to stimulate histidine-rich protein synthesis molecular markers of epidermocyte differentiation 6-8 hours before DNA synthesis. Epidermal chalones stimulate 3H-leucine incorporation into urine-dissolving proteins of the epidermis and diminish histidine-rich protein synthesis. These data suggest that chalones not only inhibit the epidermocyte proliferative activity, but also influence the processes of its differentiation.
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