These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of 2-nicotinamidoethyl nitrate (SG-75) on pancreatic secretion in the isolated, blood-perfused pancreas of the dog.
    Author: Iwatsuki K, Ikeda K, Chiba S.
    Journal: Clin Exp Pharmacol Physiol; 1981; 8(6):585-90. PubMed ID: 6460573.
    Abstract:
    1. The effects of 2-nicotinamidoethyl nitrate (SG-75) on the secretion of pancreatic juice were compared with those of acetylcholine, secretin and pancreozymin in the isolated, blood-perfused dog pancreas. 2. Intra-arterial administration of SG-75 (0.3-3 mg) elicited a dose-dependent increase in pancreatic secretion. Acetylcholine (10-100 micrograms), secretin (0.03-0.3 units) and in pancreozymin (0.1-1.0 units) also elicited increased secretion. 3. Secretory responses to acetylcholine were inhibited by treatment with atropine, while SG-75-, secretin-, and pancreozymin-induced secretions were not modified. 4. Bicarbonate concentrations in pancreatic juice induced by SG-75 and secretin were increased in a dose-dependent manner. However, there were slight changes with acetylcholine or pancreozymin. 5. Amylase activity in pancreatic juice was increased by SG-75, acetylcholine and pancreozymin, but was decreased by secretin. 6. These results suggest that SG-75 stimulates pancreatic secretion by acting both on the acinar and ductular cells of the dog pancreas.
    [Abstract] [Full Text] [Related] [New Search]